17. Zhang S, Masuyer G, Zhang J, Shen Y, Lundin D, Henriksson L, Miyashita S, Martinez-Carranza M, Dong M*, Stenmark P* (2017). Identification and characterization of a novel botulinum neurotoxin. Nature Communications (in press). * co-corresponding authors.

16. Tao L, Zhang J, Meraner P, Tovaglier A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M (2016). Frizzled proteins are colonic epithelial receptor for C. difficile toxin BNature (article, 538: 350-355, doi:10.1038/nature19799).

— “Research Highlight” Nature Reviews Microbiology 

http://www.nature.com/nrmicro/journal/v14/n11/full/nrmicro.2016.152.html

15. Yao G*, Zhang S*, Mahrhold S*, Lam K, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A**, Dong M**, Jin R**(2016). N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nature Structure and Molecular Biology, 23, 656-662. * co-first author; ** co-corresponding authors.

 -- “News and Views”   Nature Structure & Molecular Biology, 2016, 23:619-621.

14. Lee K, Zhong X, Gu S, Kruel AM, Dornet MB, Perry K, Rummel A, Dong M, Jin R (2014). Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex. Science, 344:1405-10.

13. Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, Tepp WH, Zhang SC, Johnson EA, Sawyer SL and Dong M (2014).Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins. PLoS Pathogen 10(7):e1004177, PMCID: PMC 4092145.

12. Berntsson RP-A, Peng L, Svensson LM, Dong M, Stenmark P (2013). Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II. Structure, 21:1602. PMC3803103.

11. Berntsson RP-A, Peng L, Dong M, Stenmark P (2013). Structure of Dual Receptor Binding to Botulinum Neurotoxin B. Nature Communications, 4:2058. PMC3752466.

10. Peng L, Liu H, Ruan H, Tepp WH, Stoothoff WH, Brown RH, Johnson EA, Yao WD, Zhang SC, and Dong MCytotoxicity of Botulinum Neurotoxins Reveals Essential Neuronal Plasma Membrane SNAREs. Nature Communications2013; 4:1472. 

   -- Harvard News report: http://hms.harvard.edu/news/new-wrinkle-botox-3-26-13

   -- Faculty of 1000 recommended

9. Peng L, Berntsson RP-A, Tepp WH, Pitkin RM, Johnson EA, Stenmark P, and Dong M (2012). Botulinum neurotoxin D-C uses synaptotagmin I/II as receptors and human synaptotagmin II is not an effective receptor for type B, D-C, and G toxins. J. Cell Science,125:3233 (PMCID in progress). 

   — Comments in J. Cell Science (2012), 125:e1306

   — 2012 Roger T. Kelleher Award from the New England Primate Center for outstanding research paper

8. Peng L, Tepp WH., Johnson EA., Dong M (2011). Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors. PLoS Pathogen, 7:e1002008. PMCID: PMC3068998

   — 2010 Roger T. Kelleher Award from the New England Primate Center for outstanding research paper

 

Publications in Edwin Chapman’s lab, University of Wisconsin and HHMI:

7. Dong M, Liu H, Tepp WH, Johnson EA, Janz R, Chapman ER (2008).“Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons”Mol. Bio. Cell, 19(12):5226  

6. Dong M, Tepp WH, Liu H, Johnson EA, Chapman ER (2007). “Mechanism of BoNT/B and G entry into hippocampal neurons”J. Cell Biol., 179(7):1511 

5. Chai Q*, Arndt JW*, Dong M*, Tepp WH, Johnson EA, Chapman ER, Stevens RC (2006). “Structural basis of cell surface receptor recognition by botulinum neurotoxin B”, Nature, 444 (7122) :1096  (*equal contribution) 

   -- Comments in: Nature (2006), Dec 21;444(7122):1019-20

                             Nature Struct. Mol. Biol. (2007), Jan;14(1):9-10

4. Dong M, Yeh F, Tepp WH, Dean C, Johnson EA, Janz R, Chapman ER (2006). “SV2 is the protein receptor for botulinum neurotoxin A”Science, 312(5773):592 

   -- Comments in: Science (2006), Apr 28;312(5773):540-1“A Neuronal Receptor for Botulinum Toxin”.

                           Nature Reviews Neuroscience (2006), vol.7, pp.420-421“Illicit entry”. 

                           Chemical Biology (2006), vol.1, pp.117..  “Botox on the Brain”.

                           Physiology (2006), vol.21, pp. 229“Highlights

3. Dong M, Tepp WH, Johnson EA, Chapman ER (2004). “Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells”PNAS (USA), 101(41): 14701 

    -- This study has led to the creation of a biotech company, BioSentinel LLC, to commercialize the inventions. 

2. Dong M, Richards DA, Goodnough MC, Tepp WH, Johnson EA, Chapman ER (2003). “Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells”J.Cell Biol., 162(7):1293 

    --  Comments inJournal of Cell Biology (2003), vol.162, pp.1178. “How to block Botox”.

1. Lewis JL, Dong M, Earles CA, Chapman ER (2003). “The transmembrane domain of syntaxin 1A is critical for cytoplasmic domain protein-protein interaction”J. Biol. Chem., 276(18):15458

© Dong Lab updated July 2016